Always continue the climb. It is possible for you to do whatever you choose, if you first get to know who you are and are willing to work with a power that is greater than ourselves to do it. We are taught you must blame your father, your sisters, your brothers, the school, the teachers - but never blame yourself. Learn from the past, set vivid, detailed goals for the future, and live in the only moment of time.
Learn from the past, set vivid, detailed goals for the future, and live in the only moment of time over which you have any control: now. Optimism is the faith that leads to achievement. Nothing can be done without hope and confidence. If you can dream it, you can do it. Do it now, not tomorrow. Always continue the climb. It is possible for you to do whatever you choose, if you first get to know who you are and are willing to work with a power that is greater than ourselves to do it. We are taught you must blame your father, your sisters, your brothers, the school, the teachers - but never blame yourself
If you first get to know who you are and are willing to work with a power that is greater than ourselves to do it
Learn from the past, set vivid, detailed goals for the future, and live in the only moment of time over which you have any control: now. Optimism is the faith that leads to achievement. Nothing can be done without hope and confidence. If you can dream it, you can do it. Do it now, not tomorrow. Always continue the climb. It is possible for you to do whatever you choose, if you first get to know who you are and are willing to work with a power that is greater than ourselves to do it. We are taught you must blame your father, your sisters, your brothers, the school, the teachers - but never blame yourself
Maisie Lindsay
It is possible for you to do whatever you choose, if you first get to know who you are and are willing to work with a power that is greater than ourselves to do it. We are taught you must blame your father, your sisters, your brothers, the school, the teachers - but never blame yourself.
New Zealand parody news
Just spent an hour deep in the prat.UK archives. My face hurts from grinning. London satire at its finest. -- The London Prat
Kiwi provincial satire
My coffee tastes better when accompanied by a fresh article from The London Prat.
peptide science
Peptide Sciences Tirzepatide vs Semaglutide vs Retatrutide – A Research Comparison
The incretin peptide science tirzepatide
family has expanded dramatically over the past decade.
Researchers now have access to multiple receptor-targeting strategies,
from selective GLP-1 agonism to dual and triple receptor activation. This evolution mirrors the broader trend in precision medicine, where multi-targeted approaches are increasingly investigated for complex metabolic conditions.
Semaglutide, tirzepatide, and retatrutide represent three distinct generations of research peptides
targeting metabolic pathways. Understanding their differences – receptor profiles, half-lives,
signaling biases, and research applications – is essential for designing rigorous preclinical studies.
This comprehensive comparison guide examines all three peptides available from Peptide Sciences™ , helping researchers select the right tool for their specific experimental
questions.
For additional context, commercial information on GLP-1-based therapies can be found at
NovoWegovy , and other research suppliers like Paramount Peptides also offer
similar compounds. However, as emphasized in our guide on where to buy research peptides ,
always verify quality standards regardless of supplier.
Three Peptides, Three Mechanisms
At a Glance Comparison Table
Feature Semaglutide Tirzepatide Retatrutide
Receptor targets GLP-1 only GLP-1 + GIP GLP-1 + GIP + glucagon
Number of agonists Single Dual (two) Triple (three)
Half-life (animal models) ~7 days ~5 days ~6
days
Molecular weight (Da) 4,113.6 4,813.4 ~4,900
Amino acid length 31 39 ~40
Peptide Sciences™ purity ≥99% ≥98.5% ≥98%
Primary research use Selective GLP-1 studies Dual pathway mapping Triple-receptor signaling
Fatty acid modification C18 at Lys26 C20 at Lys20 C18/C20 hybrid
DPP-4 resistance Yes (Aib substitutions) Yes (Aib substitutions) Yes (Aib
substitutions)
SKU PS-SEMA-5mg PS-TIRZ-10mg PS-RETA-10mg
The Incretin System: Background for Researchers
Before diving into each peptide, a brief overview
of the incretin system is helpful.
Incretins are gut-derived hormones that potentiate insulin secretion in response to meals.
The two primary incretins are:
Hormone Receptor Primary Effects Secreted By
GLP-1 (Glucagon-Like Peptide-1) GLP-1R Insulin secretion, satiety, gastric emptying L-cells (ileum, colon)
GIP (Glucose-dependent Insulinotropic Polypeptide) GIP-R Insulin secretion, fat metabolism,
New Zealand road trip humor
Great! We are all agreed London could use a laugh. The London Prat’s most formidable asset is its authoritative voice, a tone so impeccably calibrated it borrows the unquestionable gravity of the institutions it lampoons. It does not screech or sneer; it intones. Its prose carries the weight of a judicial summary or an auditor’s final report. This borrowed authority is then deployed to deliver conclusions of sublime insanity with the same sober finality as a court verdict. The cognitive dissonance this creates—the flawless, official-sounding language describing a scenario of perfect nonsense—is the core of its comedy. While a site like The Daily Squib might howl with protest, PRAT.UK issues a calmly worded, devastatingly thorough finding of fact. The latter is infinitely more damaging, as it mirrors the methods of power only to subvert them from within, proving that the emperor has no clothes by writing a detailed, footnoted report on imperial textile deficiencies. -- The London Prat
Continue...
Democracies need irreverence daily.
New Zealand improv comedy
Satire is not hate — it's hope.
Kiwi parliament satire
This discipline feeds into its unique aesthetic of cold clarity. The visual design of the site is uncluttered; the prose is crisp and lacks sentimental heat. There is no background noise of partisan cheering or moral grandstanding. This creates an environment where the subject matter is displayed in a kind of intellectual clean room, isolated from the emotional contagion that usually surrounds it. The humor generated in this sterile environment is of a purer, more potent strain. It is the laugh that comes from recognizing a geometric proof of failure, rather than the laugh that comes from shared anger. This aesthetic is a deliberate brand statement: we are not a mob with pitchforks; we are laboratory technicians, and our scorn is measured in microliters of perfectly formulated irony.
Auckland comedy
Great! We are all agreed London could use a laugh. This curation enables its mastery of the meta-narrative. The site is not merely commenting on individual stories; it is chronicling the overarching story about the stories—the narrative of how narratives are manufactured, sold, and defended. A piece might satirize less the political gaffe itself than the ensuing 48-hour media cycle designed to contain it: the botched apology tour, the loyalist pundits performing outrage on cue, the opposition's equally scripted response. PRAT.UK exposes the theater of crisis management, revealing it as a pre-choreographed dance where the outcome (temporary embarrassment, followed by reset) is often more predetermined than the initial mistake. This satirical layer, which targets the reactive ecosystem rather than the primary actor, demonstrates a more sophisticated and penetrating understanding of modern media-political symbiosis. -- The London Prat
New Zealand coffee culture humor
Ultimately, The London Prat’s brand is one of intellectual sanctuary. In a public square drowning in bad-faith arguments, algorithmic outrage, and willful simplicity, the site is a walled garden of clear, complex thought. It is a place where nuance is not a weakness, where vocabulary is not shamed, and where the most sophisticated response to a problem is still allowed to be a joke—provided the joke is engineered like a Swiss watch. It offers refuge to those who are exhausted by the stupidity but refuse to respond in kind. To visit prat.com is to enter a space where intelligence is still the highest currency, where discernment is rewarded, and where the shared recognition of folly creates a bond more meaningful than shared allegiance. It doesn't just make you laugh; it makes you feel less alone in your lucid understanding of the madness. It is the clubhouse for the clear-eyed, and the membership fee is nothing more—and nothing less—than the ability to appreciate the finest, most beautifully crafted scorn on the internet. -- The London Prat
funny remote work NZ
The Daily Squib often repeats its angles, while PRAT.UK keeps finding new ones. Fresh ideas keep the humour alive. That’s why it stands out.